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Clinical Trials

At the forefront of research

NCH participates in a variety of clinical trials to evaluate the effectiveness of new medicines, therapies and treatments. Part of this effort is to make sure that physicians have access to the latest and most advanced research. We participate in national research programs for a variety of diseases including breast, prostate and brain cancers.

Specific clinical trials include:

  • The study of conventional whole breast irradiation versus partial breast irradiation in various stages of breast cancer
  • New finger joint replacement for the treatment of arthritis due to trauma or systemic causes (Rheumatoid or Osteoarthritis)
  • Double-blind, placebo-controlled study to evaluate the efficacy of Zometa for the prevention of osteoporosis and associated fractures in patients receiving radiation therapy and long term LHRH agonists for high-grade and/or locally advanced prostate cancer
  • Molecular epidemiology case-series study of on-small cell lung cancer in smokers and non-smokers – men and women
  • Phase III randomized trial of the role of whole brain radiation therapy in addition to radio surgery in patients with one to three cerebral metastases
Clinical Trials
Disease or Site Principal Investigator Web Section Link Protocol Title/Number
Heart Roger Nissen, M.D. Cardiology NCH 01-11 JOMED JOSTENT Coronory Stent Graft
Arthritis - Finger Prosthesis Jay Pomerance, M.D. Ortho NCH 02-02 Avanta Proximal Interphalangeal Joint (PIP) Finger Prosthesis
Arthritis - Finger Joint Jay Pomerance, M.D. Ortho NCH 02-05 New Finger Joint Replacement for the Treatment of Arthritis Due to Trauma of Systemic Causes (Rheumatoid or Osteoarthritis) (MCP)
Implant as substitute for long bone nonunion fractures Bryan Neal, MD Ortho NCH 03-16 OP-1 Implant
Breast Cancer Stephen Nigh, M.D. Cancer Services/Breast Center NCH 05-06 NCICIRB #04-015 A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer (NSABP B-39/RTOG 04-13)
Ovarian or Primary Peritoneal Cancer Josh Tunca, M.D. Cancer Services NCH 05-12 NCICIRB #04-026 A Randomized Phase III Trial of Maintenance Chemotherapy Comparing 12 Monthly Cycles of Single Agent Paclitaxel or Xyotax (CT-2103) (IND #70177) Versus No Treatment until Documented Relapse in Women with Advanced Ovarian or Primary Peritoneal Cancer who Achieve a Complete Clinical Response to Primary Platinum/Taxane Chemotherapy
Endometrial Cancer Josh Tunca, M.D. Cancer Services NCH 05-13 NCICIRB #03-005 A Randomized Phase III Trial of Doxorubicin/Cisplatin/Paclitaxel/G-CSF Versus Carboplatin/Paclitaxel in Patients with Stage III & IV or Recurrent Endometrial Cancer (GOG 02-09)
Rectal Cancer Najeeb Mohideen, M.D. Cancer Services NCH 06-04 ACOSOG Study Z06041: A Phase II Trial of Neoadjuvant Chemoradiation and Local Excision for uT2uN0 Rectal Cancer
Cancer Stephen Nigh, M.D. Cancer Services/CyberKnife NCH 06-09 Evaluation of the CyberKnife Stereotactic Radiation Delivery System for Treatment of Cranial, Spinal, and Other Lesions
Ovarian/Primary Peritoneal Cancer Josh Tunca, M.D. Cancer Services NCH 06-10 NCICIRB #05-109 A Phase III Trial of Carboplatin and Paclitaxel Plus Placebo Versus Carboplatin and Paclitaxel Plus Concurrent Bevacizumab (NSC #704865), IND #7921) Followed by Placebo, Versus Carboplatin and Paclitaxel Plus Concurrent and Extended Bevacizumab, in Women with newly Diagnosed, Previously Untreated, Stage III or IV Epithelial Ovarian or Primary Peritoneal Cancer GOG 02-18
Assessment of Cancer Tests Stephen Nigh, M.D. Cancer Services NCH 06-14 (CIRB) ECOG PACCT-1 Program for the Assessment of Clinical Cancer Tests (PACCT-1): Trial Assigning Individualized Options for Treatment:  The TAILORx Trial
Prostate Cancer Stephen Nigh, M.D. Cancer Services, Prostate NCH 07-03 (CIRB) A Phase III Protocol of Androgen Suppression (AS) and 3DCRT/IMRT vs. AS and 3DCRT/IMRT Followed by Chemotherapy with Docetaxel and Prednisone for Localized, High-Risk Prostate Cancer RTOG 05-21
Breast Implants M. Vincent Makhlouf, M.D. Cancer Services/Breast Center NCH 07-04 Memorygel Postapproval Study for Mentor Silicone Gel-Filled Breast Implants
Breast Implants Chris Pelletiere, M.D. Cancer Services/ Breast Center NCH 07-05 Memorygel Postapproval Study for Mentor Silicone Gel-Filled Breast Implants
Breast Implants Sam Speron, M.D. Cancer Services/Breast Center NCH 07-07 Memorygel Postapproval Study for Mentor Silicone Gel-Filled Breast Implants
Lung Cancer/Smoking Stephen Nigh, MD Cancer Services NCH 07-09 S0424 Molecular Epidemiology Case-Series Study of Non-Small Cell Lung Cancer in Smoking and Non-Smoking Women and Men
Non Small Lung Cancer & Brain Metastases Stephen Nigh, M.D. Cancer Services NCH 07-12 (CIRB) A Phase III Trial Comparing Whole Brain Radiation and Steriotactic Radiosurgery Alone Versus with Temozolomide or Erlotinib in Patients with Non-small Lung Cancer and 1-3 Brain Metastases RTOG 03-20
Prostate Cancer Stephen Nigh, M.D. Cancer Services/Prostate NCH 07-13 A Phase III, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Zometa for the Prevention of Osteoporosis and Associated Fractures in Patients Receiving Radiation Therapy and Long Term LHRH Agonists for High-Grade and/or Locally Advanced Prostate Cancer RTOG 05-18
Lung, Breast & Prostate Cancer Stephen Nigh, M.D. Cancer Services NCH 07-14 Randomized Phase III Trial to Evaluate Radiopharmaceuticals and Zoledronic Acid in the Palliation of Osteoblastic Metastases from Lung, Breast, and Prostate Cancer RTOG 05-17
Lung Cancer - CyberKnife Stephen Nigh, M.D. Cancer Services NCH 07-17 A Prospective Evaluation of Outcomes of Radiosurgical Treatment of Early Stage Non-small Cell Lung Cancer (NSCLC) ACCL001.0
Pediatric Voiding Cystourethrography (VCUG) Carl Kalbhen, M.D. Pediatrics NCH 07-18 Anxioloysis with Oral Midazolam for Pediatric Voiding Cystourethrography (VCUG) Examinations: Experience at a Community Hospital
Cardiac Study John Beshai, MD Cardiology NCH 07-21 FREEDOM – A Frequent Optimization Study using the QuickOptTM Method
Cardiac Study Martin Burke, DO Cardiology NCH 07-23 First Arrhythmia Collection of Transvenous and Simultaneous Subcutaneous Implantable Defibrillator (S-ICD) Data (FACT S- ICD) Study
Brain Cancer Stephen Nigh, M.D. Cancer Services NCH 07-28 (CIRB) NCCTG N0574 Phase III Randomized Trial of the Role of Whole Brain Radiation Therapy in Addition to Radiosurgery in Patients with One to Three Cerebral Metastases
Post Marketing Study Smajo Osmanovic, MD Ophthalmology/Surgical? NCH 07-35 The Effects of Latanoprost, Bimatoprost, and Travoprost on Periocular Skin Pigmentation
Prostate Cancer - CyberKnife Najeeb Mohideen, MD Cancer Services/Prostate/ CyberKnife NCH 07-36 Prospective Evaluation of CyberKnife Stereotactic Radiosurgery for Low and Intermediate Risk Prostate Cancer: Homogenous Dose Distribution
Lung Cancer Stephen Nigh, MD Cancer Services NCH 08-01 RTOG 06-18 A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Patients with Operable Stage I/II Non-Small Cell Lung Cancer
CyberKnife Registry Stephen Nigh, MD Cancer Services/CyberKnife NCH 08-04 ReCKordTM – CyberKnife® Registry Protocol
Ovarian, Fallopian Tube & Peritoneal Primary Cancer Josh Tunca, MD Cancer Services NCH 08-05 (CIRB) GOG 02-13 A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel Alone or in Combination with Bevacizumab (NSC #704865, IND #7921) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Fallopian Tube and Peritoneal Primary Cancer, NCI-Supplied Agents: Bevacizumab (NSC #704865, IND #7921)
Infection Control – Clostridium Difficile Maryann Gierloff, RN Quality Control/Infection Control NCH 08-07 National U.S. Inpatient Healthcare Facility Clostridium Difficile Survey
Sepsis Induced Cardiovascular/Respiratory Failure Nathan Lidsky, MD Cardiology NCH 08-08 Takeda, Protocol, TAK-242_301: A Randomized, Double-Blind Placebo-Controlled Study of the Efficacy and Safety of TAK-242 Versus Placebo in Subjects with Sepsis Induced Cardiovascular and Respiratory Failure
Cervical Cancer Stephen Nigh, MD
Josh Tunca, MD
Philip Lobo, MD
Najeeb Mohideen, MD		 Cancer Services NCH 08-10 RTOG 0417 A Phase II Study of Bevacizumab in Combination with Definitive Radiotherapy and Cisplatin Chemotherapy in Untreated Patients with Locally Advanced Cervical Carcinoma
Mental Health – Adolescents - School Refusal Treatment Program Tahseen Mohammed MD
Maggie Hahn, RN		 Mental Health/Adolescent Services/School Refusal NCH 08-11 Initial Efficacy Study of a Hospital-Based School Refusal Treatment Program
Perinatal Cardiac Database Nina Gotteiner, MD Pediatrics NCH 08-12 Perinatal Cardiac Database Protocol
Humanitarian Use Device Ali Shaibani, MD Diagnostic Imaging NCH 08-15 FDA HDE Approved Humanitarian Use Device
Diagnostic Imaging CORDIS ENTERPRISETM Vascular Reconstruction Device and Delivery System
Diabetes In Teens Jill Weissberg-Benchell, Ph.D. Diabetes Services NCH 08-16 Teaching Healthy Thinking in Teens with Type I Diabetes
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Last Updated 04/10/2009